Module Link: http://drupal.org/project/filedepot The filedepot module allows you to upload files to Drupal as well as configure permissions, mark favorites, broadcast messages and even version files. (It has a Windows client too)
Who: Technical users* (This is too generic, you'll have to listen to the podcast) When: Use this module when you want to allow users to upload files and create folders and need very fine grained permissions as well as versioning. Where: You can find your configuration options at admin/settings/filedepot and you can upload/modify files at /filedepot. I couldn't find any real CCK or WYSIWYG integration so /filedepot appears to be the only place you can access it from. Why: Drupal does need a strong file manager that works well remotely with a multi-user environment. This module is a half step in this direction. If it could provide good CCK and WYSIWYG integration this module could be the de facto file manger for Drupal.