A few weeks ago, a post on Clay Smith’s Journal Feedabout the new IDSA C diff guidelines caught my attention (specifically, that metronidazole is no longer recommended as first line therapy). Whuut? I tweeted this and @medquestioningtweeted back, "Need to dig to see why they dropped metro in the bucket." Yes, @medquestioning, my thoughts exactly. Mentioned in this episode ERcast 2.0launches May 1, 2018 To sign up for the new site and 1 year of free CME, click here Essentials of Emergency Medicineis just around the corner. If you can't make it to Vegas, the digital live stream is pretty sweet. New IDSA C Diff Guideline Treatment Recommendations Initial Episode, Non Severe (WBC ≤ 15k, creatinine < 1.5) First Line Vancomycin 125 mg PO QID for 10 days Fidaxomicin 200mg PO BID for 10 days Second line Metronidazole 500mg TID PO for 10 days Initial Episode, Severe (WBC >15k, creatinine >1.5) Vancomycin 125 mg PO QID for 10 days Fidaxomicin 200mg PO BID for 10 days Initi
